LGR5 and colorectal carcinoma: Lineage tracing of LGR5‐EGFP+ CRC cells in organoid‐derived xenografts demonstrated their self‐renewal and ability to differentiate into mucosecreting‐ and absorptive‐like phenotypes in vivo, thereby providing convincing evidence for LGR5 as a bona fide TIC marker in human CRC.