APMAP and obesity due to melanocortin 4 receptor deficiency: Together, our data suggest that APMAP is anovel regulator of extracellular matrix components, and establish that APMAP is apotential target to mitigate obesity-associated insulinresistance.—Pessentheiner, A. R., Huber, K., Pelzmann, H. J., Prokesch, A.,Radner, F. P. W., Wolinski, H., Lindroos-Christensen, J., Hoefler, G.,Rülicke, T., Birner-Gruenberger, R., Bilban, M., Bogner-Strauss, J. G. APMAPinteracts with lysyl oxidase–like proteins, and disruption ofApmap leads to beneficial visceral adipose tissue expansion.