Futhermore, tumor cells secrete the PGK1, which restricts blood vessel formation, whilst in tumor metastasis foci, the high expression of CXCL12/CXCR4 pathway can down-regulate PGK1 expression and consequently overcome the vascular inhibition produced by PGK1 to promote tumor growth [34]. The gene discussed is CXCL12; the disease is neoplasm.