Aiming to explore the role of SDF-1α/CXCR4 signaling pathway in the clinicopathological features and prognosis of patients with NPC, the study conducted a series of experiments and finally concludes that the protein expressions of SDF-1α/CXCR4 might be associated with the clinicopathological features and and their high protein expressions were risk factors for the prognosis of NCP patients. Here, CXCR4 is linked to nasopharyngeal carcinoma.