CXCR4 and nasopharyngeal carcinoma: In conclusion, our study provides strong evidence that the high expressions of SDF-1α and CXCR4 proteins in SDF-1α/CXCR4 signaling pathway are related to the pathogenesis of NPC, and overexpression of SDF-1α and CXCR4 may be a risk factor for the prognosis of the NPC patients, indicating they can provide novel and effective strategies for the treatment of NPC.