The post hoc analysis on CpG sites replicated in the NHBCS cohort and related to genes enriched in KEGG pathways for cardiovascular disease and diabetes led to the identification of five CpG sites cg25189764, cg08198265, cg04986899, cg10473311 and cg04903360 located on genes FYN, BST1, XYLT1, PTPRN2 and PARD3, respectively. This evidence concerns the gene PTPRN2 and cardiovascular disorder.