Management of KS-IRIS has not been studied in controlled trials, but as opposed to some cases of Mycobacterium infection and cryptococcosis [9], corticosteroids are contraindicated in KS-IRIS, since it may further exacerbate KS lesions due to the synergy of cytokines with glucocorticoid receptors in KS spindle cells [22, 44, 45]. Here, NR3C1 is linked to cryptococcosis.