NFATC3 and cardiac hypertrophy: The up-regulation of miR-328 expression suppresses its target gene SERCA2a (ATPase Sarcoplasmic/Endoplasmic Reticulum Ca2+ Transporting 2) in cardiac myocytes to indirectly activate the calcineurin/NFATc3 signaling pathway, leading to cardiac hypertrophy [33].