For instance, 10 established driver cancer genes in BRCA (BCL2, CCND1, CCNE2, CDC42, CDKN1B, EGR1, FOS, HMGA2, NRAS and RB1) and PRAD (BCL2, CDKN1B, EGR1, HIF1A, JUN, KIT, MAP4K4, MYC, RB1 and STAT3) were significantly downregulated when their Hermes-inferred ceRNAs were silenced but were unaffected by silencing of negative control genes (i.e., genes not predicted as their cognate ceRNA regulators); see Figs. 1b-c, 2 and 3. The gene discussed is STAT3; the disease is cancer.