PSEN2 and early-onset autosomal dominant Alzheimer disease: These CMs contain not only genes from KEGG AD pathways, including BACE1, GSK3B, MAPK1, PSEN2, CALM1, CALM2, CASP8, and SK3B; but also interesting genes with relevant biological functions such as GABRB1, MMP2, CDK17, and IGFBP3. In sum, besides confirming previous findings (e.g., APOE, TOMM40, APOC1), this study has also suggested new susceptible genes, CMs and pathways underlying Alzheimer’s disease.