APOE and Alzheimer disease: Among these genes, apolipoprotein C1 (ApoC1) encoded by the APOC1 gene is associated with amyloid β plaques; the APOE and TOMM40 (rs769449) genes code for proteins related to the clearance of Aβ and mitochondrial functions [5, 13]; and the PVRL2 gene was previously reported as related to risk factors that contribute to AD pathogenesis [46].