This current study includes only newly diagnosed metastatic PCa patients and found that a PSA nadir >4 ng/mL was associated with earlier clinical progression; this is similar to findings of Hussain et al. in their study cohort of metastatic PCa patients who were treated with 7-month “induction” course of Goserelin and bicalutamide [7]. This evidence concerns the gene KLK3 and posterior cortical atrophy.