While pretreatment PSA, PSA velocity and Gleason score have been found to be important predictors of response to therapy and survival in the setting of localized disease [11, 12]; alkaline phosphatase, PSA nadir and time to PSA nadir, PSA half-life have been reported to predict survival following PADT for advanced or metastatic disease [6, 7, 10, 13–17]. This evidence concerns the gene KLK3 and metastatic neoplasm.