HMGB1 and Miyoshi myopathy: Another interesting candidate is the hyperacetylated isoform of the protein HMGB1, determined by mass spectrometry, reaching a maximum AUC of 1.00 when comparing serum levels of MM patients with asbestos-exposed individuals [35], while for the gene product TXN (thioredoxin) AUCs of 0.82 and 0.72 were reported by Maeda et al. and Demir et al., respectively [36, 37].