However, the exact role of IFI27 in the RV infection physiopathology is still unknown, although based on our results we can suggest that RV infection might activate an interferon-mediated mechanism of mucosal recovery after infection damage through a pathway mediated by IFI27. The observed association between IFI27 expression and EGF requires a more in-depth analysis, and the mechanistic approach needs to be clarified. Here, EGF is linked to infection.