VEGFA and diabetes mellitus: As, angiogenesis and capillary density decreases in heart of diabeticrats.18 Similarly,clinical studies have shown an abnormality in endothelium dependent vasodilation inpatients with diabetes.19 Diabeteshas been shown to cause structural and functional disturbances in the myocardiumthrough myocardial fibrosis, collagen formation, myocyte hypertrophy, mitochondrialdysfunction, and ROS accumulation.20 It has been found that cardiac expression of VEGF-A and itsreceptors decreased in diabetic rats and in the human myocardium withdiabetes.21