Successively, in vitro functionalstudies showed that the identified mutation resulted in the loss of RAD51 focusformation in response to DNA damage, a defect that could be rescued by the ectopicexpression of wild-type RAD51C. On this basis, the authors proposedto assign the acronym FANCO to RAD51C. RAD51C is also recognized as a gene associated with breast andovarian cancer predisposition (Somyajit etal., 2012). This evidence concerns the gene RAD51C and cancer.