XRCC2 belongs to a group of RAD51 paralogs, which includes RAD51B, C and D.Therefore, with XRCC2/FANCU, the list of genes of which inactivatingmutations could be associated with an FA-like phenotype and with breast cancerpredisposition and/or homologous recombination now includes BRCA2, BRCA1,PALB2, BRIP1/BACH1, RAD51 and RAD51C. The gene discussed is BRCA2; the disease is Friedreich ataxia.