PALB2 and Friedreich ataxia: Reidet al. (2007) followed a candidate gene approach,sequencing 82 FA patients with unelucidated genetic causes and identified mutationsinactivating PALB2 in 7 individuals belonging to independent families. By Westernblot analysis, Xia and collaborators noticed the lack of a full-length PALB2 in anunassigned FA cell line. Subsequent DNA sequencing allowed the identification of theinactivating mutations in PALB2 (Xiaet al., 2007).