As illustrated in Fig 1A, the median plasma levels of HMGB1 was 9.89 (2.85–23.15) ng/ml in pAPS patients, 8.99 (1.71–18.18) ng/ml in APA+SLE patients, 8.09 (2.68–19.17) ng/ml in APS+SLE patients, and 10.70 (5.58–16.15) ng/ml in HCs. This evidence concerns the gene HMGB1 and autoimmune polyendocrinopathy.