Making use of data of the Mtb-infected macrophage transcriptome (at 4 h and 24 h post-infection) available from our laboratory, we narrowed down on a set of transcription factors that are reportedly important players in M1/M2 macrophage polarization [34], namely KLF4, C/EBPβ and CREB. This evidence concerns the gene CREB1 and infection.