Interestingly, DEK knockdown repressed LDHA expression according to a previously published RNA sequencing study (S1A and S1B Fig), and repressed other key metabolic enzymes that drive glucose metabolism in HNSCC such as FASN [56, 57], PDK1 [58], PKM2 [59–61], and HK2 [62]. This evidence concerns the gene LDHA and head and neck squamous cell carcinoma.