Recently, Farah et al. [11] showed that inhibition of mTOR signaling by rapamycin increased the expression of LC3-II and autophagic vesicles in the livers of young global G6pc-/- mice and suggested that activation of mTOR signaling may underlie hepatic autophagy deficiency in GSD-Ia. The gene discussed is G6PC1; the disease is hyperinsulinemic hypoglycemia, familial, 4.