Moreover, overexpression of SK4 in MDA‐MB‐231 cells increased primary tumour growth and metastasis (Thurber et al., 2017), whereas TRAM‐34 at concentrations known to inhibit plasma membrane SK4 channels stimulates the proliferation of MCF‐7 cells presumably by a mechanism that involves oestrogen receptors (Roy et al., 2010). This evidence concerns the gene KCNN4 and neoplasm.