We detected a high RPA3 expression level in HNE1 cells, a relatively radioresistant cell line, and a low RPA3 expression in the radiosensitive NPC cell line CNE2, and RPA3 expression tended to positively correlate with radioresistance in the seven NPC cell lines used in this study (Fig. S1). Here, RPA3 is linked to nasopharyngeal carcinoma.