TGFB1 and Leukoencephalopathy: TGFβ deregulation in the vessel wall is a central mechanism common to several hereditary brain microvasculopathies, like cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy [CADASIL; 18] or cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy [CARASIL, 3, 49].