Additional sensitivity analyses were performed by (i) censoring individuals after a stroke, (ii) only using clinical dementia diagnoses from the SATSA, OCTO-Twin, GENDER and HARMONY studies, (iii) using a strict definition of CAD as defined in the CAD GWAS,9 (iv) using a strict definition of the GRS excluding rs2075650 on the basis of proximity to the APOE gene and (v) adjusting for APOE genotype. The gene discussed is APOE; the disease is Stroke.