Additional sensitivity analyses were performed by (i) censoring individuals after a stroke, (ii) only using clinical dementia diagnoses from the SATSA, OCTO-Twin, GENDER and HARMONY studies, (iii) using a strict definition of CAD as defined in the CAD GWAS,9 (iv) using a strict definition of the GRS excluding rs2075650 on the basis of proximity to the APOE gene and (v) adjusting for APOE genotype. This evidence concerns the gene APOE and stroke disorder.