COMT and 22q11.2 deletion syndrome: When considering the entire group of patients with 22q11DS, no significant effects of the COMT genotype (F1,89<23.79, P>0.05) or significant interactions between genotype–sex (F1,89<20.65, P>0.05) and genotype–puberty (F1,89<19.33, P>0.05) were observed.