COMT and 22q11.2 deletion syndrome: Only few studies investigated the effect of COMT genetics on working memory and brain morphology during development,13, 15, 17 showing increased cognitive performance with age15 and faster rates of cortical thinning17 in MetMet subjects, as well as potential COMT-by-puberty interaction in Met homozygous males.13 In our translational study combining results from patients with 22q11DS and COMT genetically modified mice, we demonstrated that puberty is the developmental period when COMT-by-sex interactions start to appear, influencing cortical morphology as well as related cognitive functions.