COMT and 22q11.2 deletion syndrome: In agreement with the results from 22q11DS human patients (Figure 1), and conversely to male humans and mice,31 VBM gray matter mapping revealed bilateral foci of decreased cortical volume in female COMT−/− compared with COMT+/+ (P<0.05, threshold free cluster enhancement (TFCE) corrected; Figure 2a), and COMT+/− littermates (P<0.05, TFCE corrected; Figure 2b).