Recently, we reported a volume reduction in the thickness of the left lateral orbitofrontal cortex and a significant inverse correlation with serum cortisol levels in patients with MDD.21 We did not, however, find a correlation between the volume reduction in the left temporal pole and the plasma cortisol levels in patients with MDD carrying the PCLO SNP rs2522833 C-allele. Here, PCLO is linked to major depressive disorder.