The identified downstream targets of miR-365 include cell division cycle 25A (CDC25A), cyclin D1 (CCND1), transcription termination factor 1 (TTF1), interleukin 6 (IL-6) and nuclear factor I B (NFIB) in various types of cancers [13,14,15,16,17,18,19]. This evidence concerns the gene CCND1 and cancer.