For example, our RNA-seq analyses demonstrated that inhibition of HIF-1α in DF-treated ECs rescued the expression of anti-inflammatory molecules KLF2, KLF4, and PPAP2B (a coronary arterial disease candidate gene identified by genome-wide association studies) (SenBanerjee et al., 2004; Wu et al., 2015). This evidence concerns the gene KLF4 and coronary artery disorder.