In Saos‐2 osteosarcoma cells, transfection of WNT receptor low‐density lipoprotein receptor‐related protein 5 (LRP5) caused a marked upregulation of E‐cadherin and downregulation of N‐cadherin and was associated with reduced activity of the transcription factors SNAI2 and Twist (Guo et al., 2007). This evidence concerns the gene CDH1 and osteosarcoma.