THBS1 and schistosomiasis: Since we found evidence that BM-derived Ly6C+ monocytes were the source of TSP-schistosomiasis-induced PH, we investigated the expression of chemokines that can recruit these cells to the lung perivascular compartment; we found higher mRNA levels of Ccl2, Ccl7 and Ccl12 (the ligands for CCR2, the receptor on Ly6C+ monocytes) in sorted tissue or interstitial macrophages specifically, (Supplementary Fig. 15).