To elucidate the effect of Mac-1 on the development of arterial thrombosis in real-time, carotid arteries of wild-type (WT) and Mac-1−/− mice were subjected to the Rose Bengal model of thrombosis, an endothelial cell photochemical injury model due to local free radical release28, 29. The gene discussed is ITGB2; the disease is deep vein thrombosis.