While animal models of anxiety-like behaviors have traditionally used assays such as the elevated plus-maze, open field tests, etc. we have employed a discriminative fear conditioning paradigm that allowed us to examine the effects of mGluR5 activation on both specific and non-specific fear within the same experimental framework (Botta et al., 2015; Duvarci et al., 2009). The gene discussed is GRM5; the disease is Anxiety.