To qualify as ICD, dying tumor cells must possess characteristics associated with immune signal 0 (danger) and signal 3 (inflammatory cytokines) that are required to instruct host DCs to take up tumor cell bodies, to mature and process these antigens into MHC-presented peptides, and to cross-prime antitumor T cells in a manner that results in the activation and expansion of cytotoxic T cells capable of emigration back to sites of disease. This evidence concerns the gene HLA-C and neoplasm.