CD8A and neoplasm: Briefly, this has been shown through multiple approaches including the use of (1) an OV encoding a tumor antigen to potently activate therapeutic T cell responses (5); (2) reovirus infection of tumor cells to prime antitumor immunity capable of reducing metastatic disease burden (6); and (3) CD8+ T cell depletion resulting in the loss of efficacy associated with OV-based treatment (7).