In glioma cells and pulmonary artery smooth muscle cells, the 5-HT2A receptor co-immunoprecipitates with cav-1 (Bhatnagar et al., 2004; Cogolludo et al., 2006), and in cardiomyocytes with cav-3 (Mialet-Perez et al., 2012). This evidence concerns the gene CAV3 and central nervous system cancer.