CRP and Hand-foot syndrome: Additionally, the effects of N-caffeoyltryptamine on plasma sE-selectin were investigated using the same blood samples, because this protein is also considered a reliable atherosclerotic risk factor [29], As with the CRP, the supplementation provided no significant difference between the C, HF, and HFS groups (Figure 7), although the mean values of plasma sE-selectin were slightly different in the HF and HFS groups.