Because plasma levels of MCP-1 are commonly used as a risk indicator for CVD including atherosclerosis [11,12], and because a high-calorie diet often increases plasma levels of the MCP-1 protein in humans [24], these data suggest that N-caffeoyltryptamine may have positive effects in lowering the plasma levels of MCP-1 in individuals with cardiovascular risks fed a high-calorie diet. The gene discussed is CCL2; the disease is atherosclerosis.