PDK1 and ovarian cancer: Of note, previous reports showed that COL11A1 elevates phosphorylated Akt in ovarian cancer cells by stabilizing PDK1 [26], and FLT4 participates in the induction of phosphorylation of extracellular signal-regulated kinase (ERK) 1/2 as well as in the proliferative and migratory ability of SG-2 cells [31].