It induces a variety of responses in hematopoietic tissues, signalling mainly through the IL4Rα subunit, which is present in many tissue types including hematopoietic, endothelial, epithelial, muscle, fibroblast, hepatocyte and brain.33, 34, 35 Using a TMA, we were able to demonstrate that IL4Rα is significantly overexpressed in luminal PCa cells compared to cells from benign areas of the human prostate. This evidence concerns the gene IL4R and posterior cortical atrophy.