This hypothesis is supported by previous findings, which have demonstrated that (i) knockdown of STAT6 expression can inhibit tumour metastasis in PCa, (ii) STAT6−/− mice are resistant to metastatic disease and (iii) STAT6 phosphorylation promotes metastatic potential in colon cancer cells.43, 44, 45 However, epithelial to mesenchymal transition has also been linked to increased clonogenicity, and may play a role in the observed results.46 This evidence concerns the gene STAT6 and neoplasm.