The bulk of prostate adenocarcinomas consist of luminal cancer cells, precluding analysis of the IL4Rα expression levels in rare cell populations such as the basal cell compartment in malignant areas.12, 28 Due to these technical limitations, the detection of rare basal cell populations in human tissue by immunohistochemical methods is highly challenging. The gene discussed is IL4R; the disease is prostate adenocarcinoma.