STAT6 and posterior cortical atrophy: In vitro and in vivo studies with the STAT6 inhibitor Leflunomide have reported reduced growth and promotion of apoptosis in PCa.47 However, Leflunomide is known to have non-specific effects and can alter targets other than STAT6.30, 48, 49 Recently, Nagashima et al.49 synthesized the potent and selective STAT6 inhibitor AS1517499, which has been utilised in this study.