Cell surface glycosylation, affecting the interactions between proteins, regulates membrane protein organization.27 Abnormal sialylation was found in many cancers, potentially affecting tumor cell differentiation, adhesiveness and invasion.28 Here, we examined the expression and localization of ST6Gal-I and sialylation in liver tumor specimens because hepatocytes are known to produce these proteins in large quantities. The gene discussed is ST6GAL1; the disease is neoplasm.