ST6GAL1 and neoplasm: It has been reported that the high expression of ST6Gal-I increases in the levels of α2,6-sialylation, and correlates with tumorigenesis and tumor progression.16, 17, 18 Lu et al.19 showed that α2,6-sialylated glycans can promote the malignant phenotypes of many tumors by regulating the related signaling pathways.