In vascular atherogenic remodeling process, OPG could be increased due to a secondary compensatory mechanism activation [31], and higher OPG serum levels have been associated with coronary atherosclerosis [32], silent myocardial ischemia, increased CV mortality [33], myocardial infarction, and heart failure prognosis [34]. The gene discussed is TNFRSF11B; the disease is heart failure.