CCL2 and stroke disorder: As consequence of inflammation, neurogenesis is activated in stroke (Wang et al., 2011; Katajisto et al., 2015) supported by soluble factors such as bone morphogenic protein (Forni et al., 2013), retinoic acid (Plane et al., 2008), sonic hedgehog (Cheng et al., 2015), C-C motif chemokine Ligand 2 (CCL2) (Osman et al., 2016) along with SDF1 and angiopoietin-2 (Ang2) that home NSC progenitors to the site of injury (Thored et al., 2006), where they improve functional recovery (Guzman et al., 2008) and differentiate into neurons (Darsalia et al., 2007).