As consequence of inflammation, neurogenesis is activated in stroke (Wang et al., 2011; Katajisto et al., 2015) supported by soluble factors such as bone morphogenic protein (Forni et al., 2013), retinoic acid (Plane et al., 2008), sonic hedgehog (Cheng et al., 2015), C-C motif chemokine Ligand 2 (CCL2) (Osman et al., 2016) along with SDF1 and angiopoietin-2 (Ang2) that home NSC progenitors to the site of injury (Thored et al., 2006), where they improve functional recovery (Guzman et al., 2008) and differentiate into neurons (Darsalia et al., 2007). Here, ANGPT2 is linked to Stroke.