Our finding that CHX exposure also increased nuclear translocation/activation of NFκB in the context of TNFa stimulation, as well as chlamydial infection, strongly suggests that the observed CHX-dependent increase in NFκB nuclear translocation/activation upon chlamydial infection is, at least in part, due to effects independent of chlamydiae/chlamydial infection. This evidence concerns the gene NFKB1 and chlamydia trachomatis infectious disease.