In contrast, some siRNAs, such as those targeting solute carrier family 2 member 3 (SLC2A3), interferon gamma receptor 2 (IFNGR2), PDE1B, ARID1B, and EIF3A, reduced or increased bacterial load significantly at 1 day p.i. but not significantly at day 2, suggesting that these proteins are more important for the bacterial internalization or early stage of infection. This evidence concerns the gene SLC3A2 and infection.