For example, knockdown of SPTA1, ILF3, CLC, UBB, SEPX1, and PCGF5 reduced or increase the infection very significantly at both 1 and 2 days p.i., suggesting that they are critical factors exploited by Ehrlichia TRPs for bacterial survival; however, we cannot exclude the possibility that siRNAs may have different knockdown efficiency. This evidence concerns the gene ILF3 and infection.