Several studies reported that either loss of NRF2–KEAP1 interaction or point mutations in the KEAP1 or NRF2 gene are often observed in human cancers, such as renal cell carcinoma, chronic lymphocytic leukemia, esophageal squamous cell carcinoma, HCC, non-small cell lung cancer, and others (86, 87). This evidence concerns the gene NFE2L2 and hereditary clear cell renal cell carcinoma.