In agreement with the observations that changes in PPP activity may also influence the response of tumor cells to chemotherapy, it has been reported that both DHEA and 6-AN not only were able to reverse the increase of G6PD and GSH but also inhibited multidrug resistance in the doxorubicin-resistant human colon cancer cell line HT29-DX. Here, G6PD is linked to malignant colon neoplasm.