ALG2 and hereditary disease: Finally, level of Sec23a ubiquitylation should be evaluated in association with other factors that can influence COPII assembly such as the p125 protein at the ERESs [59], the Ca(2+)-dependent protein ALG2 [60, 61], the TFG1 oncoprotein [62] or in the genetic disorder Cranio-Lenticulo-Sutural Dysplasia (CLSD) caused by a SEC23A mutation that leads to abnormal endoplasmic-reticulum-to-Golgi trafficking [63].