Both male and female Addison’s and diabetes patients had normal testosterone (Figure 2) and SHBG levels [Addison’s men 28.0 ± 4.7 nmol/l (mean ± standard error of the mean), diabetes group men 34.8 ± 6.0 nmol/l: (normal range for men 13–71 nmol/l); Addison’s women 52.5 ± 8.9 nmol/l, diabetes group women 63.2 ± 10.7 nmol/l: (normal range for women 18–114)]. The gene discussed is SHBG; the disease is diabetes mellitus.