Interestingly, it has been demonstrated that BRAF-AKAP9 gene fusion leads to activate the MAPK pathway in human thyroid cancer (Ciampi et al., 2005), and AKAP9 is crucial for sertoli cell maturation and spermatogenesis in mice (Schimenti et al., 2013). The gene discussed is BRAF; the disease is thyroid gland carcinoma.