We previously reported that HSYA could attenuate BLM-induced pulmonary fibrosis (Jin et al., 2016) and inhibit TGF-β1-induced activation of human fetal lung fibroblasts (Pan et al., 2016), but the precise mechanisms and target of HSYA’s anti-fibrosis activity remain unclear. The gene discussed is TGFB1; the disease is pulmonary fibrosis.