We found the same dialysis activated Cl- currents in bone marrow derived neutrophils from CLIC1, CLCN3, CLCN7 and KCC3 KO animals and in blood neutrophils from a Bestrophinopathy patient (Best1 H178P) (Figure 7, representative current traces). The gene discussed is CLCN3; the disease is autosomal recessive bestrophinopathy.