CXCL8 and cystic fibrosis: It is well established that chronic infection sustained by the Gram-negative bacterium Pseudomonas aeruginosa (P. aeruginosa) is a hallmark of CF lung disease, which is associated with an excessive lung inflammation characterized by huge infiltrate of neutrophils in the bronchial lumen, mainly due to the release of the neutrophil chemokine IL-8 (Bonfield et al., 1995; Khan et al., 1995; Puchelle et al., 2001; Belcher and Vij, 2010).