NOS3 and cardiac hypertrophy: Moreover, impaired eNOS activity has been found in many forms of diseases such as hypertension (Chou et al., 1998), cardiac hypertrophy (Ozaki et al., 2002; Champion et al., 2004), myocardial infarction and ischemia-reperfusion injury (du Toit et al., 2007; Nakata et al., 2008), and heart failure (Couto et al., 2015).