The chemical constituents from H. erinaceus can stimulate NGF-mediated neurite outgrowth (Phan et al., 2013; Zhang et al., 2015), while Erinacine A can act as an anti-neuroinflammatory agent that confers neuroprotection in Parkinson’s disease rat model (Kuo et al., 2016). This evidence concerns the gene NGF and Parkinson disease.