IKZF1 and Autoimmunity: It is worth mentioning that most pSS-associated genes described to date play important roles in immune function rather than directly encoding salivary or lacrimal components; this is also true of IKZF1. A recent review of pSS proposed a potential framework for understanding the roles of these pSS-associated immune genes; it suggested that the risk polymorphisms could enhance the likelihood of autoimmunity, but an individual polymorphism was not sufficiently powerful to directly cause disease[36].