For example, we previously reported that the loss-of-function EPHX2 287Gln variant is associated with increased bradykinin-stimulated vasodilation in black Americans but not white Americans [37], and in the Coronary Artery Risk Development in Young Adults (CARDIA) study, the Arg287Gln polymorphism was associated with coronary artery calcification in blacks but not whites [54]. Here, EPHX2 is linked to coronary artery calcification.