In a dominant genetic model of inheritance (Arg/Arg+Lys/Arg vs. Lys/Lys), the incidence of AKI was significantly increased in patients carrying the gain-of-function 55Arg variant of sEH, 34.4%, compared to 22% in non-carriers (p = 0.01, Table 1). This evidence concerns the gene EPHX2 and acute kidney injury.