To study whether sEH activity is associated with AKI in humans, we used a candidate gene approach focused on two known functional polymorphisms of EPHX2, the gene encoding sEH: a gain-of-function polymorphism (rs41507953 or Lys55Arg) and a loss-of-function polymorphism (rs751141 or Arg287Gln) [17]. This evidence concerns the gene EPHX2 and acute kidney injury.